Stay at One of the Newest Hotels in Anderson, SC Nestled in the foothills of the Blue Ridge Mountains, Anderson, SC has plenty to offer, from historic sites to outdoor recreation. You'll find it easy to explore Upstate South Carolina when you stay at the Holiday Inn® Anderson hotel. Our great service and beautiful, contemporary decor makes us the best among full-service hotels in Anderson, SC. Just minutes from I-85 and Clemson, our hotel's location puts you close to many of the Upstate's most popular attractions. Enjoy the outdoors on the sparkling waters of Lake Hartwell. Clemson University, home of the Clemson Tigers and Death Valley Stadium, T. E. Garrison Arena and the South Carolina Botanical Gardens are all just a short drive for our guests. Corporate travelers appreciate our Anderson hotel because we're close to the area's top companies, including AnMed Healthcare, Bosch, AFCO, GNC and Glen Raven. Anderson University is just 3. 5 miles and Clemson University is 15 miles. Our hotel's business amenities include free high-speed Internet access and 1,350 sq ft of flexible function space. Other hotels in Anderson, SC can't match the services we provide, such as an outdoor pool and a state-of-the-art Fitness Center. Join us for breakfast and dinner at Dish! An American Cafe, which serves a variety of Southern specialties. Or, relax with your favorite beverage in our lounge, Lime-On-Clemson. Reserve your room to see why we're the best.