I hope you get good sleep along the way coz this might take long
There are direct trains but no direct flights for this journey. kolkata (West Bengal) to Tirupati (Andhra Pradesh) distance is 1630 km and you can get there by flight + flight in just over 6 hours or by train fares starting from ₹ 526.
The weather at Tirupati is varying from "nice" to "hotter than nice".