escape to the cape. welcome to the Hampton Inn Cape Girardeau. Cape Girardeau is situated on a hillside, and makes a handsome appearance," the great humorist and novelist Mark Twain said of our Missouri town. From the grand sweep of the Mississippi River to our well-preserved historic downtown, Cape Girardeau remains a handsome place to this day and attracts visitors from around the world. At the Hampton Inn® hotel in Cape Girardeau, we're eager to show you around. Within just a few minutes of our Hampton Inn® hotel in Cape Girardeau, visitors may spend time in Riverfront Park, where riverboats dock. Explore our historic sites and poke around our antique shops, pubs, galleries and restaurants. Catch a show or take your family to our roller-skating rink or miniature golf course. There's so much to do in and around our hotel in Cape Girardeau, you may soon find yourself saying, again and again, "Let's escape to the cape. services & amenities Here at the Hampton Inn Cape Girardeau, we're passionate about taking good care of you. That's why we offer a broad range of services and amenities to make your stay exceptional. Whether you're planning a corporate meeting or need accommodations for a family reunion or your child's sporting group, we're delighted to offer you easy planning and booking tools to make the process quick and organized. * Meetings & Events * Local Restaurant Guide.